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MGP001350

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase alpha 3
Protein EntryGSTA3_HUMAN
UniProt IDQ16772
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=23 uM for delta(5)-androstene-3,17-dione {ECO:0000269|PubMed:15595823}; Vmax=99 umol/min/mg enzyme for delta(5)-androstene-3,17-dione isomerization {ECO:0000269|PubMed:15595823};
Catalytic ActivityRX + glutathione = HX + R-S-glutathione.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. {ECO:0000269|PubMed:15595823, ECO:0000269|PubMed:20083122}.
Sequence CautionSequence=AAA74634.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD04712.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the GST superfamily. Alpha family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:15595823, ECO:0000269|PubMed:20083122}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gsta3/";
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