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MGP001351

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase alpha 4
Protein EntryGSTA4_HUMAN
UniProt IDO15217
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15217-1; Sequence=Displayed; Name=2; IsoId=O15217-2; Sequence=VSP_056473;
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}.
SimilarityBelongs to the GST superfamily. Alpha family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}.
Tissue SpecificityExpressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gsta4/";
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