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MGP001358

Record overview

MGPD IDMGP001358
Gene ID2952
SpeciesHomo sapiens (Human)
Gene Nameglutathione S-transferase theta 1
Gene Symbol GSTT1
Alternate namesglutathione S-transferase theta-1; GST class-theta-1; glutathione transferase T1-1;
Chromosome22
Map Location22q11.23
EC Number2.5.1.18
SummaryThe protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. GSTT1 and GSTT2 share 55% amino acid sequence identity and both may play an important role in human carcinogenesis. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. This GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes, which are also located on chromosome 22, have been identified. [provided by RefSeq, Jun 2014]
OrthologsView orthologs and multiple alignments for GSTT1

Proteins

glutathione S-transferase theta-1 isoform a
Refseq ID:NP_000844
Protein GI:167466164
UniProt ID:P30711
mRNA ID:NM_000853
Length:240
RefSeq Status:
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLA
WQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEA
AVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
 
glutathione S-transferase theta-1 isoform b
Refseq ID:NP_001280736
Protein GI:658309999
UniProt ID:P30711
mRNA ID:NM_001293807
Length:226
RefSeq Status:
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKDGVSLCRPGWSAVAGSQLTATSAARNLVLCLLFLLGRSALKRCLCPGEPPQEGASLEGRGLHL
DGEVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVI
LKAKDFPPADPTIKQKLMPWVLAMIR
 
glutathione S-transferase theta-1 isoform c
Refseq ID:NP_001280737
Protein GI:658310001
UniProt ID:P30711
mRNA ID:NM_001293808
Length:122
RefSeq Status:
MFPVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAK
DFPPADPTIKQKLMPWVLAMIR
 
glutathione S-transferase theta-1 isoform c
Refseq ID:NP_001280739
Protein GI:658310005
UniProt ID:P30711
mRNA ID:NM_001293810
Length:122
RefSeq Status:
Protein sequence is identical to GI:658310001 (mRNA isoform)
 
glutathione S-transferase theta-1 isoform c
Refseq ID:NP_001280741
Protein GI:658310009
UniProt ID:P30711
mRNA ID:NM_001293812
Length:122
RefSeq Status:
Protein sequence is identical to GI:658310001 (mRNA isoform)
 
glutathione S-transferase theta-1 isoform c
Refseq ID:NP_001280740
Protein GI:658310007
UniProt ID:P30711
mRNA ID:NM_001293811
Length:122
RefSeq Status:
Protein sequence is identical to GI:658310001 (mRNA isoform)
 
glutathione S-transferase theta-1 isoform c
Refseq ID:NP_001280738
Protein GI:658310003
UniProt ID:P30711
mRNA ID:NM_001293809
Length:122
RefSeq Status:
Protein sequence is identical to GI:658310001 (mRNA isoform)
 
glutathione S-transferase theta-1 isoform d
Refseq ID:NP_001280742
Protein GI:658310011
UniProt ID:
mRNA ID:NM_001293813
Length:105
RefSeq Status:
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESPWVLAAKSSKADPSWPHGGSAWRQQWGRTSSRR
PMRSF
 
glutathione S-transferase theta-1 isoform e
Refseq ID:NP_001280743
Protein GI:658310013
UniProt ID:Q4W251
mRNA ID:NM_001293814
Length:72
RefSeq Status:
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKARGCWLPSLRRPTQAGHMAAARGGSSGGGPLPGGP
 
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