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MGP001358

UniProt Annotations

Entry Information

Gene Name	glutathione S-transferase theta 1
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P30711-1; Sequence=Displayed; Name=2; IsoId=P30711-2; Sequence=VSP_056474; Note=No experimental confirmation available.;
Catalytic Activity	RX + glutathione = HX + R-S-glutathione. {ECO:0000269\|PubMed:16298388, ECO:0000269\|PubMed:20097269}.
Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. {ECO:0000269\|PubMed:16298388, ECO:0000269\|PubMed:20097269}.
Polymorphism	The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.
Similarity	Belongs to the GST superfamily. Theta family. {ECO:0000305}.
Similarity	Contains 1 GST C-terminal domain. {ECO:0000305}.
Similarity	Contains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Homodimer. {ECO:0000269\|PubMed:16298388}.
Tissue Specificity	Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles. {ECO:0000269\|PubMed:8761485}.
Web Resource	Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTT1";