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MGP001373

Record overview

MGPD IDMGP001373
Gene ID2971
SpeciesHomo sapiens (Human)
Gene Namegeneral transcription factor IIIA
Gene Symbol GTF3A
SynonymsAP2; TFIIIA;
Alternate namestranscription factor IIIA;
Chromosome13
Map Location13q12.3-q13.1
SummaryThe product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GTF3A

Proteins

transcription factor IIIA
Refseq ID:NP_002088
Protein GI:166063995
UniProt ID:Q92664
mRNA ID:NM_002097
Length:365
RefSeq Status:
MDPPAVVAESVSSLTIADAFIAAGESSAPTPPRPALPRRFICSFPDCSANYSKAWKLDAHLCKHTGERPFVCDYEGCGKAFIRDYHLSRHILTHTGEKPF
VCAANGCDQKFNTKSNLKKHFERKHENQQKQYICSFEDCKKTFKKHQQLKIHQCQHTNEPLFKCTQEGCGKHFASPSKLKRHAKAHEGYVCQKGCSFVAK
TWTELLKHVRETHKEEILCEVCRKTFKRKDYLKQHMKTHAPERDVCRCPREGCGRTYTTVFNLQSHILSFHEESRPFVCEHAGCGKTFAMKQSLTRHAVV
HDPDKKKMKLKVKKSREKRSLASHLSGYIPPKRKQGQGLSLCQNGESPNCVEDKMLSTVAVLTLG
 
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