MGP Database

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MGP001373

UniProt Annotations

Entry Information
Gene Namegeneral transcription factor IIIA
Protein EntryTF3A_HUMAN
UniProt IDQ92664
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92664-1; Sequence=Displayed; Name=2; IsoId=Q92664-2; Sequence=VSP_031525, VSP_031526;
CautionIt is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals. {ECO:0000305}.
FunctionInteracts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.
Sequence CautionSequence=BAA06988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA06988.1; Type=Frameshift; Positions=319, 330; Evidence={ECO:0000305};
SimilarityContains 9 C2H2-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00042}.
Subcellular LocationNucleus.
Tissue SpecificityUbiquitous.
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