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MGP001377

UniProt Annotations

Entry Information

Gene Name	guanylate cyclase 1, soluble, alpha 2
Protein Entry	GCYA2_HUMAN
UniProt ID	P33402
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha-2; IsoId=P33402-1; Sequence=Displayed; Name=2; Synonyms=Alpha-2-I; IsoId=P33402-2; Sequence=VSP_001814; Name=3; IsoId=P33402-3; Sequence=VSP_054154; Note=No experimental confirmation available.;
Catalytic Activity	GTP = 3',5'-cyclic GMP + diphosphate.
Enzyme Regulation	Activated by nitric oxide in the presence of magnesium or manganese ions.
Function	Has guanylyl cyclase on binding to the beta-1 subunit.
Function	Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.
Miscellaneous	There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.
Similarity	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255\|PROSITE-ProRule:PRU00099}.
Similarity	Contains 1 guanylate cyclase domain. {ECO:0000255\|PROSITE-ProRule:PRU00099}.
Subcellular Location	Cytoplasm.
Subunit	Heterodimer of an alpha and a beta chain.
Tissue Specificity	Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium.