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MGP001379

Record overview

MGPD IDMGP001379
Gene ID2982
SpeciesHomo sapiens (Human)
Gene Nameguanylate cyclase 1, soluble, alpha 3
Gene Symbol GUCY1A3
SynonymsGUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A1;
Alternate namesguanylate cyclase soluble subunit alpha-3; GC-S-alpha-1; GCS-alpha-3; soluble guanylate cyclase large subunit;
Chromosome4
Map Location4q31.1-q31.2
EC Number4.6.1.2
SummarySoluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
OrthologsView orthologs and multiple alignments for GUCY1A3

Proteins

guanylate cyclase soluble subunit alpha-3 isoform A
Refseq ID:NP_001124154
Protein GI:194595472
UniProt ID:Q02108
mRNA ID:NM_001130682
Length:690
RefSeq Status:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKH
KIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFL
HVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYL
SDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPL
QVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
 
guanylate cyclase soluble subunit alpha-3 isoform A
Refseq ID:NP_001124156
Protein GI:194595476
UniProt ID:Q02108
mRNA ID:NM_001130684
Length:690
RefSeq Status:
Protein sequence is identical to GI:194595472 (mRNA isoform)
 
guanylate cyclase soluble subunit alpha-3 isoform A
Refseq ID:NP_001243378
Protein GI:374253804
UniProt ID:Q02108
mRNA ID:NM_001256449
Length:690
RefSeq Status:
Protein sequence is identical to GI:194595472 (mRNA isoform)
 
guanylate cyclase soluble subunit alpha-3 isoform A
Refseq ID:NP_000847
Protein GI:67763816
UniProt ID:Q02108
mRNA ID:NM_000856
Length:690
RefSeq Status:
Protein sequence is identical to GI:194595472 (mRNA isoform)
 
guanylate cyclase soluble subunit alpha-3 isoform A
Refseq ID:NP_001124155
Protein GI:194595474
UniProt ID:Q02108
mRNA ID:NM_001130683
Length:690
RefSeq Status:
Protein sequence is identical to GI:194595472 (mRNA isoform)
 
guanylate cyclase soluble subunit alpha-3 isoform B
Refseq ID:NP_001124157
Protein GI:194595478
UniProt ID:
mRNA ID:NM_001130685
Length:455
RefSeq Status:
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTF
SGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKAT
LEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFT
PRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
 
guanylate cyclase soluble subunit alpha-3 isoform D
Refseq ID:NP_001124159
Protein GI:194595482
UniProt ID:Q02108
mRNA ID:NM_001130687
Length:624
RefSeq Status:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKH
KIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFL
HVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYL
SDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPL
QVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYR
 
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