MGP Database

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MGP001392

UniProt Annotations

Entry Information
Gene Namehistone cluster 1, H1c
Protein EntryH12_HUMAN
UniProt IDP16403
SpeciesHuman
Comments
Comment typeDescription
DomainThe C-terminal domain is required for high-affinity binding to chromatin. {ECO:0000250}.
FunctionHistone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
PtmCitrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250}.
PtmCrotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000269|PubMed:21925322}.
PtmH1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. {ECO:0000250}.
SimilarityBelongs to the histone H1/H5 family. {ECO:0000255|PROSITE-ProRule:PRU00837}.
SimilarityContains 1 H15 (linker histone H1/H5 globular) domain. {ECO:0000255|PROSITE-ProRule:PRU00837}.
Subcellular LocationNucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
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