MGP Database

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MGP001398

Ontology/Pathway Information

Entrez Gene ID3014
Gene NameH2A histone family, member X
Gene Symbol H2AFX
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000794 IEA:EnsemblCcondensed nuclear chromosome
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0001673 IEA:EnsemblCmale germ cell nucleus
GO:0000790 IEA:EnsemblCnuclear chromatin
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0000786 IEA:UniProtKB-KWCnucleosome
GO:0005634 IDA:UniProtKBCnucleus
GO:0005657 IEA:EnsemblCreplication fork
GO:0035861 IDA:MGICsite of double-strand break
GO:0001741 IEA:EnsemblCXY body
GO:0003684 IEA:EnsemblFdamaged DNA binding
GO:0003677 NAS:UniProtKBFDNA binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042393 IPI:UniProtKBFhistone binding
GO:0006974 IDA:BHF-UCLPcellular response to DNA damage stimulus
GO:0000077 IDA:UniProtKBPDNA damage checkpoint
GO:0006281 TAS:ReactomePDNA repair
GO:0006302 NAS:UniProtKBPdouble-strand break repair
GO:0000724 TAS:ReactomePdouble-strand break repair via homologous recombination
GO:0051321 IEA:UniProtKB-KWPmeiotic cell cycle
GO:0006334 NAS:UniProtKBPnucleosome assembly
GO:0045739 NAS:UniProtKBPpositive regulation of DNA repair
GO:0010212 NAS:UniProtKBPresponse to ionizing radiation
GO:0007283 IEA:EnsemblPspermatogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75925Amyloids
REACT_486Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
REACT_1924ATM mediated phosphorylation of repair proteins
REACT_204ATM mediated response to DNA double-strand break
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_22172Chromosome Maintenance
REACT_264303Condensation of Prophase Chromosomes
REACT_22186Deposition of new CENPA-containing nucleosomes at the centromere
REACT_116125Disease
REACT_169185DNA Damage/Telomere Stress Induced Senescence
REACT_268237DNA methylation
REACT_216DNA Repair
REACT_2054Double-Strand Break Repair
REACT_264098Epigenetic regulation of gene expression
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_71Gene Expression
REACT_1874Homologous Recombination Repair
REACT_1587Homologous recombination repair of replication-independent double-strand breaks
REACT_111183Meiosis
REACT_27271Meiotic recombination
REACT_75792Meiotic synapsis
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_1884MRN complex relocalizes to nuclear foci
REACT_264000Negative epigenetic regulation of rRNA expression
REACT_263965NoRC negatively regulates rRNA expression
REACT_22344Nucleosome assembly
REACT_169436Oxidative Stress Induced Senescence
REACT_7963Packaging Of Telomere Ends
REACT_264352PRC2 methylates histones and DNA
REACT_97Recruitment of repair and signaling proteins to double-strand breaks
REACT_12472Regulatory RNA pathways
REACT_264545RMTs methylate histone arginines
REACT_2204RNA Polymerase I Chain Elongation
REACT_1974RNA Polymerase I Promoter Clearance
REACT_2232RNA Polymerase I Promoter Opening
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_1309RNA Polymerase I Transcription
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264541SIRT1 negatively regulates rRNA Expression
REACT_264596TCF dependent signaling in response to WNT
REACT_7970Telomere Maintenance
REACT_268530Transcriptional regulation by small RNAs
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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