MGP Database

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MGP001406

UniProt Annotations

Entry Information
Gene Namehydroxyacylglutathione hydrolase
Protein EntryGLO2_HUMAN
UniProt IDQ16775
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; IsoId=Q16775-1; Sequence=Displayed; Name=2; IsoId=Q16775-2; Sequence=VSP_037929; Note=Produced by alternative splicing. Also produced by alternative initiation at Met-49 of isoform 1.; Name=3; IsoId=Q16775-3; Sequence=VSP_055199, VSP_055200; Note=No experimental confirmation available.;
Catalytic ActivityS-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.
CautionOnly one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II. {ECO:0000305}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
FunctionThiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid.
PathwaySecondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.
Sequence CautionSequence=AAH00840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA62483.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. {ECO:0000305}.
Subcellular LocationIsoform 1: Mitochondrion matrix.
Subcellular LocationIsoform 2: Cytoplasm.
SubunitMonomer. {ECO:0000269|PubMed:10508780}.
Tissue SpecificityExpressed in liver and kidney. {ECO:0000269|PubMed:15117945}.
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