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MGP001440

UniProt Annotations

Entry Information
Gene Namehexokinase 2
Protein EntryHXK2_HUMAN
UniProt IDP52789
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + D-hexose = ADP + D-hexose 6-phosphate.
DomainThe N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.
Enzyme RegulationHexokinase is an allosteric enzyme inhibited by its product Glc-6-P.
MiscellaneousIn vertebrates there are four major glucose- phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).
PathwayCarbohydrate metabolism; hexose metabolism.
PolymorphismAlthough found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
SimilarityBelongs to the hexokinase family. {ECO:0000305}.
SimilarityContains 2 hexokinase type-1 domains. {ECO:0000305}.
SimilarityContains 2 hexokinase type-2 domains. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane {ECO:0000250}. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding. {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityPredominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hk2/";
Web ResourceName=Wikipedia; Note=Hexokinase entry; URL="http://en.wikipedia.org/wiki/Hexokinase";
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