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MGP001443

UniProt Annotations

Entry Information
Gene Namemajor histocompatibility complex, class I, B
Protein Entry1B07_HUMAN
UniProt IDP01889
SpeciesHuman
Comments
Comment typeDescription
FunctionInvolved in the presentation of foreign antigens to the immune system.
PolymorphismThe following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.
PtmPolyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity). {ECO:0000250}.
SimilarityBelongs to the MHC class I family. {ECO:0000305}.
SimilarityContains 1 Ig-like C1-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I. {ECO:0000250, ECO:0000269|PubMed:11390610}.
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