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MGP001447

Record overview

MGPD IDMGP001447
Gene ID3112
SpeciesHomo sapiens (Human)
Gene Namemajor histocompatibility complex, class II, DO beta
Gene Symbol HLA-DOB
SynonymsDOB;
Alternate namesHLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB;
Chromosome6
Map Location6p21.3
SummaryHLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HLA-DOB

Proteins

HLA class II histocompatibility antigen, DO beta chain precursor
Refseq ID:NP_002111
Protein GI:4504403
UniProt ID:P13765
mRNA ID:NM_002120
Length:273
RefSeq Status:
MGSGWVPWVVALLVNLTRLDSSMTQGTDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNLEEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQA
VDGVCRHNYRLGAPFTVGRKVQPEVTVYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQEERAGVMSTGPIRNGDWTFQTVVMLEMTPELGHVYTCL
VDHSSLLSPVSVEWRAQSEYSWRKMLSGIAAFLLGLIFLLVGIVIQLRAQKGYVRTQMSGNEVSRAVLLPQSC
 
sig_peptide: 1..26
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P13765.1)
calculated_mol_wt: 2818
peptide sequence: 
MGSGWVPWVVALLVNLTRLDSSMTQG

mat_peptide: 27..273
product: HLA class II histocompatibility antigen, DO beta chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P13765.1)
calculated_mol_wt: 28022
peptide sequence: 
TDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNLEEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQAVDGVCRHNYRLGAPFTVGRKVQPEVT
VYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQEERAGVMSTGPIRNGDWTFQTVVMLEMTPELGHVYTCLVDHSSLLSPVSVEWRAQSEYSWRKML
SGIAAFLLGLIFLLVGIVIQLRAQKGYVRTQMSGNEVSRAVLLPQSC
 
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