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MGP001447

UniProt Annotations

Entry Information
Gene Namemajor histocompatibility complex, class II, DO beta
Protein EntryDOB_HUMAN
UniProt IDP13765
SpeciesHuman
Comments
Comment typeDescription
FunctionImportant modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
PolymorphismThe following alleles of DOB are known: DOB*01:01, DOB*01:02, DOB*01:03 and DOB*01:04. The sequence shown is that of DOB*01:01.
SimilarityBelongs to the MHC class II family. {ECO:0000305}.
SimilarityContains 1 Ig-like C1-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationEndosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
SubunitHeterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.
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