MGP Database

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MGP001448

Ontology/Pathway Information

Entrez Gene ID3113
Gene Namemajor histocompatibility complex, class II, DP alpha 1
Gene Symbol HLA-DPA1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IMP:UniProtKBCcell surface
GO:0030669 TAS:ReactomeCclathrin-coated endocytic vesicle membrane
GO:0030666 TAS:ReactomeCendocytic vesicle membrane
GO:0010008 IEA:UniProtKB-SubCellCendosome membrane
GO:0012507 TAS:ReactomeCER to Golgi transport vesicle membrane
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0071556 TAS:ReactomeCintegral component of lumenal side of endoplasmic reticulum membrane
GO:0005887 NAS:UniProtKBCintegral component of plasma membrane
GO:0005765 TAS:ReactomeClysosomal membrane
GO:0042613 IDA:UniProtKBCMHC class II protein complex
GO:0005886 TAS:ReactomeCplasma membrane
GO:0032588 TAS:ReactomeCtrans-Golgi network membrane
GO:0030658 TAS:ReactomeCtransport vesicle membrane
GO:0032395 NAS:UniProtKBFMHC class II receptor activity
GO:0042605 IDA:UniProtKBFpeptide antigen binding
GO:0019886 IMP:UniProtKBPantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0071346 IDA:UniProtKBPcellular response to interferon-gamma
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0006955 NAS:UniProtKBPimmune response
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0032729 IMP:UniProtKBPpositive regulation of interferon-gamma production
GO:0050870 IMP:UniProtKBPpositive regulation of T cell activation
GO:0042102 IMP:UniProtKBPpositive regulation of T cell proliferation
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_19344Costimulation by the CD28 family
REACT_75790Cytokine Signaling in Immune system
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_6900Immune System
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_121399MHC class II antigen presentation
REACT_19324PD-1 signaling
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12526TCR signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
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