MGP Database

MGP001452

Record overview

MGPD ID	MGP001452
Gene ID	3119
Species	Homo sapiens (Human)
Gene Name	major histocompatibility complex, class II, DQ beta 1
Gene Symbol	HLA-DQB1
Synonyms	IDDM1; CELIAC1; HLA-DQB;
Alternate names	HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class2 antigen; lymphocyte antigen;
Chromosome	6
Map Location	6p21.3
Summary	HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Orthologs	View orthologs and multiple alignments for HLA-DQB1

Proteins

HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor

Refseq ID:	NP_002114
Protein GI:	150418002
UniProt ID:	P01920
mRNA ID:	NM_002123
Length:	261
RefSeq Status:

`MSWKKALRIPGDLRVATVTLMLAMLSSLLAEGRDSPEDFVFQFKGMCYFTNGTERVRLVTRYIYNREEYARFDSDVGVYRAVTPQGRPDAEYWNSQKEVL EGTRAELDTVCRHNYEVAFRGILQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRG DVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGVGGFVLGLIFLGLGLIIRQRSQKGLLH`

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3287
peptide sequence: 
MSWKKALRIPGDLRVATVTLMLAMLSSLLA

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3387
peptide sequence: 
MSWKKALRIPGGLRAATVTLMLSMLSTPVAEG

mat_peptide: 33..261
product: HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1
calculated_mol_wt: 26364
peptide sequence: 
RDSPEDFVYQFKGMCYFTNGTERVRLVSRSIYNREEIVRFDSDVGEFRAVTLLGLPAAEYWNSQKDILERKRAAVDRVCRHNYQLELRTTLQRRVEPTVT
ISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKML
SGIGGFVLGLIFLGLGLIIHHRSQKGLLH

sig_peptide: 1..32
calculated_mol_wt: 3473
peptide sequence: 
MSWKKALRIPGDLRVATVTLMLAMLSSLLAEG

mat_peptide: 33..261
product: HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1
calculated_mol_wt: 26336
peptide sequence: 
RDSPEDFVFQFKGMCYFTNGTERVRLVTRYIYNREEYARFDSDVGVYRAVTPQGRPDAEYWNSQKEVLEGTRAELDTVCRHNYEVAFRGILQRRVEPTVT
ISPSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKML
SGVGGFVLGLIFLGLGLIIRQRSQKGLLH

HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor

Refseq ID:	NP_001230891
Protein GI:	345461079
UniProt ID:	P01920
mRNA ID:	NM_001243962
Length:	261
RefSeq Status:

`MSWKKALRIPGGLRAATVTLMLSMLSTPVAEGRDSPEDFVYQFKGMCYFTNGTERVRLVSRSIYNREEIVRFDSDVGEFRAVTLLGLPAAEYWNSQKDIL ERKRAAVDRVCRHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRG DVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGLLH`

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3287
peptide sequence: 
MSWKKALRIPGDLRVATVTLMLAMLSSLLA

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3387
peptide sequence: 
MSWKKALRIPGGLRAATVTLMLSMLSTPVAEG

mat_peptide: 33..261
product: HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1
calculated_mol_wt: 26364
peptide sequence: 
RDSPEDFVYQFKGMCYFTNGTERVRLVSRSIYNREEIVRFDSDVGEFRAVTLLGLPAAEYWNSQKDILERKRAAVDRVCRHNYQLELRTTLQRRVEPTVT
ISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSKML
SGIGGFVLGLIFLGLGLIIHHRSQKGLLH

HLA class II histocompatibility antigen, DQ beta 1 chain isoform 2 precursor

Refseq ID:	NP_001230890
Protein GI:	345461081
UniProt ID:	Q5SU54
mRNA ID:	NM_001243961
Length:	269
RefSeq Status:

`MSWKKALRIPGDLRVATVTLMLAMLSSLLAEGRDSPEDFVFQFKGMCYFTNGTERVRLVTRYIYNREEYARFDSDVGVYRAVTPQGRPDAEYWNSQKEVL EGTRAELDTVCRHNYEVAFRGILQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPGQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRG DVYTCHVEHPSLQSPITVEWRAQSESAQSKMLSGVGGFVLGLIFLGLGLIIRQRSQKGPQGPPPAGLLH`

`sig_peptide: 1..30 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3287 peptide sequence: MSWKKALRIPGDLRVATVTLMLAMLSSLLA`