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MGP001454

Record overview

MGPD IDMGP001454
Gene ID3122
SpeciesHomo sapiens (Human)
Gene Namemajor histocompatibility complex, class II, DR alpha
Gene Symbol HLA-DRA
SynonymsMLRW; HLA-DRA1;
Alternate namesHLA class II histocompatibility antigen, DR alpha chain; MHC cell surface glycoprotein; MHC class II antigen DRA; histocompatibility antigen HLA-DR alpha;
Chromosome6
Map Location6p21.3
SummaryHLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HLA-DRA

Proteins

HLA class II histocompatibility antigen, DR alpha chain precursor
Refseq ID:NP_061984
Protein GI:52426774
UniProt ID:P01903
mRNA ID:NM_019111
Length:254
RefSeq Status:
MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTK
RSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLL
KHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2638
peptide sequence: 
MAISGVPVLGFFIIAVLMSAQESWA

mat_peptide: 26..254
product: HLA class II histocompatibility antigen, DR alpha chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01903.1)
calculated_mol_wt: 26001
peptide sequence: 
IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELR
EPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLT
VGLVGIIIGTIFIIKGLRKSNAAERRGPL
 
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