MGP Database

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MGP001454

Ontology/Pathway Information

Entrez Gene ID3122
Gene Namemajor histocompatibility complex, class II, DR alpha
Gene Symbol HLA-DRA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0030669 TAS:ReactomeCclathrin-coated endocytic vesicle membrane
GO:0030666 TAS:ReactomeCendocytic vesicle membrane
GO:0012507 TAS:ReactomeCER to Golgi transport vesicle membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0071556 TAS:ReactomeCintegral component of lumenal side of endoplasmic reticulum membrane
GO:0005887 NAS:UniProtKBCintegral component of plasma membrane
GO:0031902 IDA:UniProtKBClate endosome membrane
GO:0005765 IDA:UniProtKBClysosomal membrane
GO:0005764 IDA:MGIClysosome
GO:0042613 IDA:UniProtKBCMHC class II protein complex
GO:0005886 IDA:MGICplasma membrane
GO:0032588 TAS:ReactomeCtrans-Golgi network membrane
GO:0030658 TAS:ReactomeCtransport vesicle membrane
GO:0023026 IDA:UniProtKBFMHC class II protein complex binding
GO:0032395 NAS:UniProtKBFMHC class II receptor activity
GO:0042605 IDA:UniProtKBFpeptide antigen binding
GO:0019886 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0002504 IDA:UniProtKBPantigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0050890 IMP:UniProtKBPcognition
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0006955 NAS:UniProtKBPimmune response
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0002503 IDA:UniProtKBPpeptide antigen assembly with MHC class II protein complex
GO:0002506 IDA:UniProtKBPpolysaccharide assembly with MHC class II protein complex
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_19344Costimulation by the CD28 family
REACT_75790Cytokine Signaling in Immune system
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_6900Immune System
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_121399MHC class II antigen presentation
REACT_19324PD-1 signaling
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12526TCR signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
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