MGP Database

MGP001466

Ontology/Pathway Information

Entrez Gene ID	3156
Gene Name	3-hydroxy-3-methylglutaryl-CoA reductase
Gene Symbol	HMGCR
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	TAS:UniProtKB	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005778	IDA:UniProtKB	C	peroxisomal membrane
GO:0050662	IDA:UniProtKB	F	coenzyme binding
GO:0042282	IDA:UniProtKB	F	hydroxymethylglutaryl-CoA reductase activity
GO:0004420	IEA:UniProtKB-EC	F	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0070402	IDA:UniProtKB	F	NADPH binding
GO:0007568	IEA:Ensembl	P	aging
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0006695	TAS:Reactome	P	cholesterol biosynthetic process
GO:0015936	IEA:InterPro	P	coenzyme A metabolic process
GO:0008299	IEA:InterPro	P	isoprenoid biosynthetic process
GO:0045445	IEA:Ensembl	P	myoblast differentiation
GO:0061179	IEA:Ensembl	P	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043407	IEA:Ensembl	P	negative regulation of MAP kinase activity
GO:0010664	IEA:Ensembl	P	negative regulation of striated muscle cell apoptotic process
GO:0045908	IEA:Ensembl	P	negative regulation of vasodilation
GO:0061045	IEA:Ensembl	P	negative regulation of wound healing
GO:0010666	IEA:Ensembl	P	positive regulation of cardiac muscle cell apoptotic process
GO:0070374	IEA:Ensembl	P	positive regulation of ERK1 and ERK2 cascade
GO:0048643	IEA:Ensembl	P	positive regulation of skeletal muscle tissue development
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0032874	IEA:Ensembl	P	positive regulation of stress-activated MAPK cascade
GO:0051262	IDA:UniProtKB	P	protein tetramerization
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006743	IEA:Ensembl	P	ubiquinone metabolic process
GO:0008542	IEA:Ensembl	P	visual learning

SMP Pathway Links

SMP ID	Description
SMP00095	Alendronate Action Pathway
SMP00131	Atorvastatin Action Pathway
SMP00111	Cerivastatin Action Pathway
SMP00387	CHILD Syndrome
SMP00508	Cholesteryl ester storage disease
SMP00388	Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
SMP00386	Desmosterolosis
SMP00119	Fluvastatin Action Pathway
SMP00209	Hypercholesterolemia
SMP00509	Hyper-IgD syndrome
SMP00079	Ibandronate Action Pathway
SMP00099	Lovastatin Action Pathway
SMP00319	Lysosomal Acid Lipase Deficiency (Wolman Disease)
SMP00510	Mevalonic aciduria
SMP00117	Pamidronate Action Pathway
SMP00089	Pravastatin Action Pathway
SMP00112	Risedronate Action Pathway
SMP00092	Rosuvastatin Action Pathway
SMP00082	Simvastatin Action Pathway
SMP00389	Smith-Lemli-Opitz Syndrome (SLOS)
SMP00023	Steroid Biosynthesis
SMP00511	Wolman disease
SMP00107	Zoledronate Action Pathway