MGP Database

MGP001467

Ontology/Pathway Information

Entrez Gene ID	3157
Gene Name	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Gene Symbol	HMGCS1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0005634	IDA:HPA	C	nucleus
GO:0005886	IDA:HPA	C	plasma membrane
GO:0008144	IEA:Ensembl	F	drug binding
GO:0004421	TAS:ProtInc	F	hydroxymethylglutaryl-CoA synthase activity
GO:0016853	IEA:Ensembl	F	isomerase activity
GO:0043177	IEA:Ensembl	F	organic acid binding
GO:0007420	IEA:Ensembl	P	brain development
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0071397	IEA:Ensembl	P	cellular response to cholesterol
GO:0071372	IEA:Ensembl	P	cellular response to follicle-stimulating hormone stimulus
GO:0006695	TAS:Reactome	P	cholesterol biosynthetic process
GO:0008299	IEA:InterPro	P	isoprenoid biosynthetic process
GO:0006629	NAS:ProtInc	P	lipid metabolic process
GO:0001889	IEA:Ensembl	P	liver development
GO:0008584	IEA:Ensembl	P	male gonad development
GO:0042493	IEA:Ensembl	P	response to drug
GO:0055094	IEA:Ensembl	P	response to lipoprotein particle
GO:0009645	IEA:Ensembl	P	response to low light intensity stimulus
GO:0014074	IEA:Ensembl	P	response to purine-containing compound
GO:0046690	IEA:Ensembl	P	response to tellurium ion
GO:0033197	IEA:Ensembl	P	response to vitamin E
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_147904	Activation of gene expression by SREBF (SREBP)
REACT_9405	Cholesterol biosynthesis
REACT_22279	Fatty acid, triacylglycerol, and ketone body metabolism
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_116145	PPARA activates gene expression
REACT_147797	Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_19241	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

SMP Pathway Links

SMP ID	Description
SMP00095	Alendronate Action Pathway
SMP00131	Atorvastatin Action Pathway
SMP00111	Cerivastatin Action Pathway
SMP00387	CHILD Syndrome
SMP00508	Cholesteryl ester storage disease
SMP00388	Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
SMP00386	Desmosterolosis
SMP00119	Fluvastatin Action Pathway
SMP00209	Hypercholesterolemia
SMP00509	Hyper-IgD syndrome
SMP00079	Ibandronate Action Pathway
SMP00099	Lovastatin Action Pathway
SMP00319	Lysosomal Acid Lipase Deficiency (Wolman Disease)
SMP00510	Mevalonic aciduria
SMP00117	Pamidronate Action Pathway
SMP00089	Pravastatin Action Pathway
SMP00112	Risedronate Action Pathway
SMP00092	Rosuvastatin Action Pathway
SMP00082	Simvastatin Action Pathway
SMP00389	Smith-Lemli-Opitz Syndrome (SLOS)
SMP00023	Steroid Biosynthesis
SMP00511	Wolman disease
SMP00107	Zoledronate Action Pathway