MGP Database

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MGP001467

UniProt Annotations

Entry Information
Gene Name3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Protein EntryHMCS1_HUMAN
UniProt IDQ01581
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
FunctionThis enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Sequence CautionSequence=AAH00297.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the HMG-CoA synthase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
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