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MGP001469

Record overview

MGPD IDMGP001469
Gene ID3159
SpeciesHomo sapiens (Human)
Gene Namehigh mobility group AT-hook 1
Gene Symbol HMGA1
SynonymsHMG-R; HMGIY; HMGA1A;
Alternate nameshigh mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group protein A1; high mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y;
Chromosome6
Map Location6p21
SummaryThis gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HMGA1

Proteins

high mobility group protein HMG-I/HMG-Y isoform a
Refseq ID:NP_665906
Protein GI:22208967
UniProt ID:P17096
mRNA ID:NM_145899
Length:107
RefSeq Status:
MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQ
ESSEEEQ
 
high mobility group protein HMG-I/HMG-Y isoform a
Refseq ID:NP_665908
Protein GI:22208971
UniProt ID:P17096
mRNA ID:NM_145901
Length:107
RefSeq Status:
Protein sequence is identical to GI:22208967 (mRNA isoform)
 
high mobility group protein HMG-I/HMG-Y isoform b
Refseq ID:NP_665909
Protein GI:22208973
UniProt ID:P17096
mRNA ID:NM_145902
Length:96
RefSeq Status:
MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQESSEEEQ
 
high mobility group protein HMG-I/HMG-Y isoform b
Refseq ID:NP_665912
Protein GI:22208979
UniProt ID:P17096
mRNA ID:NM_145905
Length:96
RefSeq Status:
Protein sequence is identical to GI:22208973 (mRNA isoform)
 
high mobility group protein HMG-I/HMG-Y isoform b
Refseq ID:NP_665910
Protein GI:22208975
UniProt ID:P17096
mRNA ID:NM_145903
Length:96
RefSeq Status:
Protein sequence is identical to GI:22208973 (mRNA isoform)
 
high mobility group protein HMG-I/HMG-Y isoform b
Refseq ID:NP_002122
Protein GI:4504433
UniProt ID:P17096
mRNA ID:NM_002131
Length:96
RefSeq Status:
Protein sequence is identical to GI:22208973 (mRNA isoform)
 
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