MGP Database

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MGP001469

UniProt Annotations

Entry Information
Gene Namehigh mobility group AT-hook 1
Protein EntryHMGA1_HUMAN
UniProt IDP17096
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=HMG-I; Synonyms=HMGA1a; IsoId=P17096-1; Sequence=Displayed; Name=HMG-Y; Synonyms=HMGA1b; IsoId=P17096-2; Sequence=VSP_002182; Note=Contains a phosphothreonine at position 42. Contains a phosphothreonine at position 67.; Name=HMG-R; Synonyms=HMGA1c; IsoId=P17096-3; Sequence=VSP_018084;
DiseaseNote=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.
FunctionHMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
InteractionQ96LA8:PRMT6; NbExp=4; IntAct=EBI-746854, EBI-912440;
Mass SpectrometryMass=11750; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl and 2 phosphate groups.; Evidence={ECO:0000269|PubMed:15835918};
Mass SpectrometryMass=11765; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 1 methyl and 2 phosphate groups.; Evidence={ECO:0000269|PubMed:15835918};
Mass SpectrometryMass=11780; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 2 methyl and 2 phosphate groups.; Evidence={ECO:0000269|PubMed:15835918};
Mass SpectrometryMass=11828; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl and 3 phosphate groups.; Evidence={ECO:0000269|PubMed:15835918};
Mass SpectrometryMass=11844; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 1 methyl and 3 phosphate groups.; Evidence={ECO:0000269|PubMed:15835918};
Mass SpectrometryMass=11858; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 2 methyl and 3 phosphate groups.; Evidence={ECO:0000269|PubMed:15835918};
PtmConstitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity. {ECO:0000269|PubMed:12653562, ECO:0000269|PubMed:15835918, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:17525332, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}.
PtmHMG-Y is not methylated.
PtmMethylation at Arg-58 is mutually exclusive with methylation at Arg-60. {ECO:0000269|PubMed:16159886}.
SimilarityBelongs to the HMGA family. {ECO:0000305}.
SimilarityContains 3 A.T hook DNA-binding domains. {ECO:0000305}.
Subcellular LocationNucleus. Chromosome.
SubunitInteracts with HIPK2 (By similarity). Interacts with HIV- 1 pre-integration complex. {ECO:0000250}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HMGIYID221.html";
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