MGP Database

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MGP001471

Ontology/Pathway Information

Entrez Gene ID3162
Gene Nameheme oxygenase (decycling) 1
Gene Symbol HMOX1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005901 IEA:EnsemblCcaveola
GO:0005829 IEA:EnsemblCcytosol
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0005615 TAS:BHF-UCLCextracellular space
GO:0016020 TAS:ProtIncCmembrane
GO:0005730 IEA:EnsemblCnucleolus
GO:0005634 ISS:BHF-UCLCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0019899 ISS:BHF-UCLFenzyme binding
GO:0020037 IDA:BHF-UCLFheme binding
GO:0004392 IMP:UniProtKBFheme oxygenase (decyclizing) activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004630 IEA:EnsemblFphospholipase D activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0004871 IMP:UniProtKBFsignal transducer activity
GO:0001525 TAS:BHF-UCLPangiogenesis
GO:0008219 ISS:BHF-UCLPcell death
GO:0006879 TAS:ReactomePcellular iron ion homeostasis
GO:0071243 IEA:EnsemblPcellular response to arsenic-containing substance
GO:0071276 IEA:EnsemblPcellular response to cadmium ion
GO:0071456 IEP:UniProtKBPcellular response to hypoxia
GO:0031670 IEA:EnsemblPcellular response to nutrient
GO:0001935 TAS:BHF-UCLPendothelial cell proliferation
GO:0034101 IMP:BHF-UCLPerythrocyte homeostasis
GO:0007588 IC:BHF-UCLPexcretion
GO:0042167 IDA:BHF-UCLPheme catabolic process
GO:0006788 IDA:BHF-UCLPheme oxidation
GO:0035556 TAS:BHF-UCLPintracellular signal transduction
GO:0008630 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0055072 IDA:BHF-UCLPiron ion homeostasis
GO:0034383 TAS:BHF-UCLPlow-density lipoprotein particle clearance
GO:0043392 IEA:EnsemblPnegative regulation of DNA binding
GO:1902042 IMP:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0002686 TAS:BHF-UCLPnegative regulation of leukocyte migration
GO:0032764 IEA:EnsemblPnegative regulation of mast cell cytokine production
GO:0043305 IEA:EnsemblPnegative regulation of mast cell degranulation
GO:0010656 IEA:EnsemblPnegative regulation of muscle cell apoptotic process
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0043433 IEA:EnsemblPnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0048662 IDA:UniProtKBPnegative regulation of smooth muscle cell proliferation
GO:0006778 TAS:ReactomePporphyrin-containing compound metabolic process
GO:0045766 IEA:EnsemblPpositive regulation of angiogenesis
GO:0045080 TAS:BHF-UCLPpositive regulation of chemokine biosynthetic process
GO:0043123 IMP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048661 IDA:UniProtKBPpositive regulation of smooth muscle cell proliferation
GO:0045909 IC:BHF-UCLPpositive regulation of vasodilation
GO:0051260 IDA:UniProtKBPprotein homooligomerization
GO:0045765 TAS:BHF-UCLPregulation of angiogenesis
GO:0008217 IEA:EnsemblPregulation of blood pressure
GO:0051090 ISS:BHF-UCLPregulation of sequence-specific DNA binding transcription factor activity
GO:0034395 IEA:EnsemblPregulation of transcription from RNA polymerase II promoter in response to iron
GO:0043619 ISS:BHF-UCLPregulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0042542 ISS:BHF-UCLPresponse to hydrogen peroxide
GO:0035094 IDA:BHF-UCLPresponse to nicotine
GO:0006979 IMP:BHF-UCLPresponse to oxidative stress
GO:0007264 IEA:EnsemblPsmall GTPase mediated signal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0014806 TAS:BHF-UCLPsmooth muscle hyperplasia
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0002246 IMP:BHF-UCLPwound healing involved in inflammatory response
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22297Heme degradation
REACT_25060Iron uptake and transport
REACT_111217Metabolism
REACT_9431Metabolism of porphyrins
REACT_15518Transmembrane transport of small molecules
SMP Pathway Links
SMP IDDescription
SMP00344Acute Intermittent Porphyria
SMP00345Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
SMP00342Hereditary Coproporphyria (HCP)
SMP00346Porphyria Variegata (PV)
SMP00024Porphyrin Metabolism
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