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MGP001472

Record overview

MGPD IDMGP001472
Gene ID3163
SpeciesHomo sapiens (Human)
Gene Nameheme oxygenase (decycling) 2
Gene Symbol HMOX2
SynonymsHO-2;
Alternate namesheme oxygenase 2;
Chromosome16
Map Location16p13.3
EC Number1.14.99.3;
SummaryHeme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
OrthologsView orthologs and multiple alignments for HMOX2

Proteins

heme oxygenase 2 isoform a
Refseq ID:NP_001273196
Protein GI:555943918
UniProt ID:P30519
mRNA ID:NM_001286267
Length:370
RefSeq Status:
MESRSVAQAGVQWISLAHCSLHLLGSRDSPASASCVAGITGPEEREQQEPHPAAMSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHD
RAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEP
ELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLAR
ETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM
 
heme oxygenase 2 isoform b
Refseq ID:NP_001120676
Protein GI:187761307
UniProt ID:P30519
mRNA ID:NM_001127204
Length:316
RefSeq Status:
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFP
MELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQ
LYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFIL
AAGVALAAGLLAWYYM
 
heme oxygenase 2 isoform b
Refseq ID:NP_001273198
Protein GI:555943922
UniProt ID:P30519
mRNA ID:NM_001286269
Length:316
RefSeq Status:
Protein sequence is identical to GI:187761307 (mRNA isoform)
 
heme oxygenase 2 isoform b
Refseq ID:NP_001273197
Protein GI:555943920
UniProt ID:P30519
mRNA ID:NM_001286268
Length:316
RefSeq Status:
Protein sequence is identical to GI:187761307 (mRNA isoform)
 
heme oxygenase 2 isoform b
Refseq ID:NP_001120678
Protein GI:187761311
UniProt ID:P30519
mRNA ID:NM_001127206
Length:316
RefSeq Status:
Protein sequence is identical to GI:187761307 (mRNA isoform)
 
heme oxygenase 2 isoform b
Refseq ID:NP_001120677
Protein GI:187761309
UniProt ID:P30519
mRNA ID:NM_001127205
Length:316
RefSeq Status:
Protein sequence is identical to GI:187761307 (mRNA isoform)
 
heme oxygenase 2 isoform b
Refseq ID:NP_002125
Protein GI:8051608
UniProt ID:P30519
mRNA ID:NM_002134
Length:316
RefSeq Status:
Protein sequence is identical to GI:187761307 (mRNA isoform)
 
heme oxygenase 2 isoform b
Refseq ID:NP_001273199
Protein GI:555943924
UniProt ID:P30519
mRNA ID:NM_001286270
Length:316
RefSeq Status:
Protein sequence is identical to GI:187761307 (mRNA isoform)
 
heme oxygenase 2 isoform c
Refseq ID:NP_001273200
Protein GI:555943926
UniProt ID:P30519
mRNA ID:NM_001286271
Length:287
RefSeq Status:
MADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPK
AAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEY
NMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM
 
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