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MGP001479

Record overview

MGPD IDMGP001479
Gene ID3176
SpeciesHomo sapiens (Human)
Gene Namehistamine N-methyltransferase
Gene Symbol HNMT
SynonymsHMT; HNMT-S1; HNMT-S2;
Alternate nameshistamine N-methyltransferase;
Chromosome2
Map Location2q22.1
EC Number2.1.1.8;
SummaryIn mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HNMT

Proteins

histamine N-methyltransferase isoform 1
Refseq ID:NP_008826
Protein GI:5901970
UniProt ID:P50135
mRNA ID:NM_006895
Length:292
RefSeq Status:
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKE
LVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYIT
SDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
 
histamine N-methyltransferase isoform 2
Refseq ID:NP_001019245
Protein GI:66932963
UniProt ID:P50135
mRNA ID:NM_001024074
Length:51
RefSeq Status:
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRYQNCC
 
histamine N-methyltransferase isoform 3
Refseq ID:NP_001019246
Protein GI:66932965
UniProt ID:P50135
mRNA ID:NM_001024075
Length:126
RefSeq Status:
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGADCLIRGSSRVLKRNSCFILCSTRQKDKPGMRIHDERS
SELPFGAARLESKSAFPSFLVSFILF
 
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