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MGP001479

UniProt Annotations

Entry Information
Gene Namehistamine N-methyltransferase
Protein EntryHNMT_HUMAN
UniProt IDP50135
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P50135-1; Sequence=Displayed; Name=2; Synonyms=HNMT-S; IsoId=P50135-2; Sequence=VSP_042027; Note=Has no histamine-methylating activity.; Name=3; IsoId=P50135-3; Sequence=VSP_043482, VSP_043483; Note=No experimental confirmation available.;
Catalytic ActivityS-adenosyl-L-methionine + histamine = S- adenosyl-L-homocysteine + N(tau)-methylhistamine. {ECO:0000255|PROSITE-ProRule:PRU00929}.
FunctionInactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
PolymorphismVariant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. {ECO:0000255|PROSITE- ProRule:PRU00929}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000269|PubMed:11566133}.
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