MGP Database

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MGP001486

UniProt Annotations

Entry Information
Gene Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Protein EntryHNRH1_HUMAN
UniProt IDP31943
SpeciesHuman
Comments
Comment typeDescription
DomainEach quasi-RRM repeat bound poly(RG), while only the N- terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).
FunctionThis protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
InductionUp-regulated in myotonic dystrophy pathophysiology (DM). {ECO:0000269|PubMed:16946708}.
SimilarityContains 3 RRM (RNA recognition motif) domains. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationNucleus, nucleoplasm.
SubunitPart of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA- dependent. Interacts with MBNL1; the interaction in RNA- independent. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:17289661}.
Tissue SpecificityExpressed ubiquitously.
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