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MGP001497

Record overview

MGPD IDMGP001497
Gene ID3265
SpeciesHomo sapiens (Human)
Gene NameHarvey rat sarcoma viral oncogene homolog
Gene Symbol HRAS
SynonymsCTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1;
Alternate namesGTPase HRas; GTP- and GDP-binding peptide B; Ha-Ras1 proto-oncoprotein; Harvey rat sarcoma viral oncoprotein; Ras family small GTP binding protein H-Ras; c-has/bas p21 protein; c-ras-Ki-2 activated oncogene; p19 H-RasIDX protein; transformation gene: oncogene HAMSV; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog;
Chromosome11
Map Location11p15.5
SummaryThis gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HRAS

Proteins

GTPase HRas isoform 1
Refseq ID:NP_001123914
Protein GI:194363762
UniProt ID:P01112
mRNA ID:NM_001130442
Length:189
RefSeq Status:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
 
GTPase HRas isoform 1
Refseq ID:NP_005334
Protein GI:4885425
UniProt ID:P01112
mRNA ID:NM_005343
Length:189
RefSeq Status:
Protein sequence is identical to GI:194363762 (mRNA isoform)
 
GTPase HRas isoform 2
Refseq ID:NP_789765
Protein GI:34222246
UniProt ID:P01112
mRNA ID:NM_176795
Length:170
RefSeq Status:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGSRSGSSSSSGTLWDPPGPM
 
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