MGP Database

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MGP001497

Ontology/Pathway Information

Entrez Gene ID3265
Gene NameHarvey rat sarcoma viral oncogene homolog
Gene Symbol HRAS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0000139 IEA:UniProtKB-SubCellCGolgi membrane
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0048471 IEA:UniProtKB-SubCellCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005525 IDA:UniProtKBFGTP binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0030036 IEA:EnsemblPactin cytoskeleton organization
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0007050 IDA:BHF-UCLPcell cycle arrest
GO:0008283 IEA:EnsemblPcell proliferation
GO:0007166 TAS:ProtIncPcell surface receptor signaling pathway
GO:0090398 IDA:BHF-UCLPcellular senescence
GO:0006935 TAS:ProtIncPchemotaxis
GO:0006897 IEA:EnsemblPendocytosis
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0060441 IEA:EnsemblPepithelial tube branching involved in lung morphogenesis
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006184 IEA:InterProPGTP catabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0097193 IEA:EnsemblPintrinsic apoptotic signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0000165 TAS:ReactomePMAPK cascade
GO:0007093 IDA:BHF-UCLPmitotic cell cycle checkpoint
GO:0045596 IEA:EnsemblPnegative regulation of cell differentiation
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0010629 IDA:BHF-UCLPnegative regulation of gene expression
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0034259 IDA:BHF-UCLPnegative regulation of Rho GTPase activity
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009887 TAS:ProtIncPorgan morphogenesis
GO:2000251 IDA:BHF-UCLPpositive regulation of actin cytoskeleton reorganization
GO:0030335 IDA:BHF-UCLPpositive regulation of cell migration
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0045740 IDA:BHF-UCLPpositive regulation of DNA replication
GO:0050679 IMP:BHF-UCLPpositive regulation of epithelial cell proliferation
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0046330 IDA:BHF-UCLPpositive regulation of JNK cascade
GO:0043410 IDA:BHF-UCLPpositive regulation of MAPK cascade
GO:0043406 IDA:BHF-UCLPpositive regulation of MAP kinase activity
GO:2000630 IDA:BHF-UCLPpositive regulation of miRNA metabolic process
GO:0001934 IDA:BHF-UCLPpositive regulation of protein phosphorylation
GO:0032855 IDA:BHF-UCLPpositive regulation of Rac GTPase activity
GO:0035022 IEA:EnsemblPpositive regulation of Rac protein signal transduction
GO:1900029 IDA:BHF-UCLPpositive regulation of ruffle assembly
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0090303 IDA:BHF-UCLPpositive regulation of wound healing
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0007265 IDA:BHF-UCLPRas protein signal transduction
GO:0048169 IEA:EnsemblPregulation of long-term neuronal synaptic plasticity
GO:0032228 IEA:EnsemblPregulation of synaptic transmission, GABAergic
GO:0007165 NAS:ProtIncPsignal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0035176 IEA:EnsemblPsocial behavior
GO:0051146 IEA:EnsemblPstriated muscle cell differentiation
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_118778Activation of RAS in B cells
REACT_75774Adaptive Immune System
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_12051Cell surface interactions at the vascular wall
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_20568CREB phosphorylation through the activation of Ras
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_121096EGFR Transactivation by Gastrin
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_962MEK activation
REACT_18334NCAM signaling for neurite out-growth
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12065p38MAPK events
REACT_20593Post NMDA receptor activation events
REACT_12005Prolonged ERK activation events
REACT_2077RAF activation
REACT_634RAF/MAP kinase cascade
REACT_614RAF phosphorylates MEK
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_21374SHC-mediated cascade
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_12621Tie2 Signaling
REACT_13477Transmission across Chemical Synapses
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00391Insulin Signalling
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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