MGP Database

MGP001502

Ontology/Pathway Information

Entrez Gene ID	3280
Gene Name	hes family bHLH transcription factor 1
Gene Symbol	HES1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0005634	ISS:UniProtKB	C	nucleus
GO:0003677	TAS:ProtInc	F	DNA binding
GO:0042826	IPI:BHF-UCL	F	histone deacetylase binding
GO:0071820	ISS:UniProtKB	F	N-box binding
GO:0042803	ISS:UniProtKB	F	protein homodimerization activity
GO:0001078	ISS:UniProtKB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0043565	ISS:UniProtKB	F	sequence-specific DNA binding
GO:0003700	IDA:UniProtKB	F	sequence-specific DNA binding transcription factor activity
GO:0008134	NAS:UniProtKB	F	transcription factor binding
GO:0021984	IEA:Ensembl	P	adenohypophysis development
GO:0048844	ISS:BHF-UCL	P	artery morphogenesis
GO:0035910	ISS:BHF-UCL	P	ascending aorta morphogenesis
GO:0042668	IEA:Ensembl	P	auditory receptor cell fate determination
GO:0061309	ISS:BHF-UCL	P	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0007155	IEA:Ensembl	P	cell adhesion
GO:0048469	IEA:Ensembl	P	cell maturation
GO:0016477	IEA:Ensembl	P	cell migration
GO:0048667	IEA:Ensembl	P	cell morphogenesis involved in neuron differentiation
GO:0090102	IEA:Ensembl	P	cochlea development
GO:0072049	IEA:Ensembl	P	comma-shaped body morphogenesis
GO:0061009	IEA:Ensembl	P	common bile duct development
GO:0003143	ISS:BHF-UCL	P	embryonic heart tube morphogenesis
GO:0031018	TAS:Reactome	P	endocrine pancreas development
GO:0021861	ISS:UniProtKB	P	forebrain radial glial cell differentiation
GO:0072012	IEA:Ensembl	P	glomerulus vasculature development
GO:0021575	IEA:Ensembl	P	hindbrain morphogenesis
GO:0060716	IEA:Ensembl	P	labyrinthine layer blood vessel development
GO:0046331	IEA:Ensembl	P	lateral inhibition
GO:0001889	IEA:Ensembl	P	liver development
GO:0030324	IEA:Ensembl	P	lung development
GO:0072282	IEA:Ensembl	P	metanephric nephron tubule morphogenesis
GO:0030901	IEA:Ensembl	P	midbrain development
GO:0021555	IEA:Ensembl	P	midbrain-hindbrain boundary morphogenesis
GO:0045608	IEA:Ensembl	P	negative regulation of auditory receptor cell differentiation
GO:2000978	ISS:UniProtKB	P	negative regulation of forebrain neuron differentiation
GO:0060253	ISS:UniProtKB	P	negative regulation of glial cell proliferation
GO:0048715	ISS:UniProtKB	P	negative regulation of oligodendrocyte differentiation
GO:2000227	IEA:Ensembl	P	negative regulation of pancreatic A cell differentiation
GO:2000974	IMP:UniProtKB	P	negative regulation of pro-B cell differentiation
GO:2000737	IMP:UniProtKB	P	negative regulation of stem cell differentiation
GO:0061106	IEA:Ensembl	P	negative regulation of stomach neuroendocrine cell differentiation
GO:0045892	IDA:BHF-UCL	P	negative regulation of transcription, DNA-templated
GO:0000122	IDA:UniProtKB	P	negative regulation of transcription from RNA polymerase II promoter
GO:0007399	TAS:ProtInc	P	nervous system development
GO:0097150	IEP:UniProtKB	P	neuronal stem cell maintenance
GO:0007219	IDA:UniProtKB	P	Notch signaling pathway
GO:0021557	IEA:Ensembl	P	oculomotor nerve development
GO:0003151	ISS:BHF-UCL	P	outflow tract morphogenesis
GO:0061626	ISS:BHF-UCL	P	pharyngeal arch artery morphogenesis
GO:0048711	ISS:UniProtKB	P	positive regulation of astrocyte differentiation
GO:0030513	IEA:Ensembl	P	positive regulation of BMP signaling pathway
GO:0008284	ISS:BHF-UCL	P	positive regulation of cell proliferation
GO:0043388	ISS:UniProtKB	P	positive regulation of DNA binding
GO:0046427	ISS:UniProtKB	P	positive regulation of JAK-STAT cascade
GO:0045977	ISS:BHF-UCL	P	positive regulation of mitotic cell cycle, embryonic
GO:0045747	IEA:Ensembl	P	positive regulation of Notch signaling pathway
GO:0042102	IEA:Ensembl	P	positive regulation of T cell proliferation
GO:0045944	ISS:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0042517	ISS:UniProtKB	P	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0006461	ISS:UniProtKB	P	protein complex assembly
GO:0045598	IEA:Ensembl	P	regulation of fat cell differentiation
GO:0003266	ISS:BHF-UCL	P	regulation of secondary heart field cardioblast proliferation
GO:0060164	IEA:Ensembl	P	regulation of timing of neuron differentiation
GO:0072141	IEA:Ensembl	P	renal interstitial fibroblast development
GO:0007224	IEA:Ensembl	P	smoothened signaling pathway
GO:0035019	IEA:Ensembl	P	somatic stem cell maintenance
GO:0072050	IEA:Ensembl	P	S-shaped body morphogenesis
GO:0007262	ISS:UniProtKB	P	STAT protein import into nucleus
GO:0021537	IEA:Ensembl	P	telencephalon development
GO:0048538	ISS:BHF-UCL	P	thymus development
GO:0021558	IEA:Ensembl	P	trochlear nerve development
GO:0060675	IEA:Ensembl	P	ureteric bud morphogenesis
GO:0097084	ISS:BHF-UCL	P	vascular smooth muscle cell development
GO:0003281	ISS:BHF-UCL	P	ventricular septum development
GO:0060412	ISS:BHF-UCL	P	ventricular septum morphogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_160254	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243	Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_111045	Developmental Biology
REACT_116125	Disease
REACT_160099	FBXW7 Mutants and NOTCH1 in Cancer
REACT_118780	NOTCH1 Intracellular Domain Regulates Transcription
REACT_163910	NOTCH2 intracellular domain regulates transcription
REACT_13698	Regulation of beta-cell development
REACT_13673	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
REACT_299	Signaling by NOTCH
REACT_118859	Signaling by NOTCH1
REACT_160133	Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214	Signaling by NOTCH1 in Cancer
REACT_160301	Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_118721	Signaling by NOTCH2
REACT_111102	Signal Transduction