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MGP001502

UniProt Annotations

Entry Information
Gene Namehes family bHLH transcription factor 1
Protein EntryHES1_HUMAN
UniProt IDQ14469
SpeciesHuman
Comments
Comment typeDescription
DomainHas a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
DomainThe bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity. {ECO:0000250}.
DomainThe C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins. {ECO:0000250}.
FunctionTranscriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
InteractionQ96EB6:SIRT1; NbExp=4; IntAct=EBI-2832522, EBI-1802965;
SimilarityContains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}.
SimilarityContains 1 Orange domain. {ECO:0000255|PROSITE- ProRule:PRU00380}.
Subcellular LocationNucleus.
SubunitTranscription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE. {ECO:0000250, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:18550849}.
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