MGP Database

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MGP001504

Ontology/Pathway Information

Entrez Gene ID3283
Gene Namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Gene Symbol HSD3B1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005743 IDA:UniProtKBCmitochondrial inner membrane
GO:0005758 IDA:UniProtKBCmitochondrial intermembrane space
GO:0030868 ISS:UniProtKBCsmooth endoplasmic reticulum membrane
GO:0003854 ISS:UniProtKBF3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769 ISS:UniProtKBFsteroid delta-isomerase activity
GO:0006702 TAS:UniProtKBPandrogen biosynthetic process
GO:0006703 TAS:UniProtKBPestrogen biosynthetic process
GO:0006704 TAS:ReactomePglucocorticoid biosynthetic process
GO:0006705 TAS:ReactomePmineralocorticoid biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006694 ISS:UniProtKBPsteroid biosynthetic process
GO:0008202 TAS:ReactomePsteroid metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11059Androgen biosynthesis
REACT_11036Glucocorticoid biosynthesis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_11047Mineralocorticoid biosynthesis
SMP Pathway Links
SMP IDDescription
SMP0057511-beta-hydroxylase deficiency (CYP11B1)
SMP0056617-alpha-hydroxylase deficiency (CYP17)
SMP0035617-Beta Hydroxysteroid Dehydrogenase III Deficiency
SMP0057621-hydroxylase deficiency (CYP21)
SMP007183-Beta-Hydroxysteroid Dehydrogenase Deficiency
SMP00373Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
SMP00372Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
SMP00068Androgen and Estrogen Metabolism
SMP00717Apparent mineralocorticoid excess syndrome
SMP00565Aromatase deficiency
SMP00371Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
SMP00577Corticosterone methyl oxidase I deficiency (CMO I)
SMP00578Corticosterone methyl oxidase II deficiency - CMO II
SMP00130Steroidogenesis
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