MGP Database

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MGP001504

UniProt Annotations

Entry Information
Gene Namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Protein Entry3BHS1_HUMAN
UniProt IDP14060
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityA 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
Catalytic ActivityA 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)- steroid.
Function3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411}.
PathwayLipid metabolism; steroid biosynthesis.
Sequence CautionSequence=AAA36001.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue SpecificityPlacenta and skin. Predominantly expressed in mammary gland tissue.
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