MGP Database

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MGP001516

Ontology/Pathway Information

Entrez Gene ID3309
Gene Nameheat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Gene Symbol HSPA5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IEA:EnsemblCcell surface
GO:0005783 IMP:UniProtKBCendoplasmic reticulum
GO:0034663 IDA:UniProtKBCendoplasmic reticulum chaperone complex
GO:0005793 IDA:UniProtKBCendoplasmic reticulum-Golgi intermediate compartment
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0030176 IDA:BHF-UCLCintegral component of endoplasmic reticulum membrane
GO:0042470 IEA:UniProtKB-SubCellCmelanosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0030496 IDA:UniProtKBCmidbody
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005634 IDA:UniProtKBCnucleus
GO:0005790 IEA:EnsemblCsmooth endoplasmic reticulum
GO:0016887 ISS:UniProtKBFATPase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005509 TAS:UniProtKBFcalcium ion binding
GO:0051087 TAS:BHF-UCLFchaperone binding
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0001948 IPI:UniProtKBFglycoprotein binding
GO:0051787 IDA:UniProtKBFmisfolded protein binding
GO:0019904 IPI:UniProtKBFprotein domain specific binding
GO:0043022 IEA:EnsemblFribosome binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0051082 TAS:UniProtKBFunfolded protein binding
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0006200 ISS:GOCPATP catabolic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0071236 IEA:EnsemblPcellular response to antibiotic
GO:0042149 IDA:UniProtKBPcellular response to glucose starvation
GO:0071353 IEA:EnsemblPcellular response to interleukin-4
GO:0021680 IEA:EnsemblPcerebellar Purkinje cell layer development
GO:0021589 IEA:EnsemblPcerebellum structural organization
GO:0030968 TAS:BHF-UCLPendoplasmic reticulum unfolded protein response
GO:0030433 TAS:BHF-UCLPER-associated ubiquitin-dependent protein catabolic process
GO:0006983 IEA:EnsemblPER overload response
GO:0035437 IMP:UniProtKBPmaintenance of protein localization in endoplasmic reticulum
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0030512 IEA:EnsemblPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0031398 IEA:EnsemblPpositive regulation of protein ubiquitination
GO:0060904 TAS:BHF-UCLPregulation of protein folding in endoplasmic reticulum
GO:0021762 IEP:UniProtKBPsubstantia nigra development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
REACT_18423ATF6-alpha activates chaperone genes
REACT_18348ATF6-alpha activates chaperones
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_604Hemostasis
REACT_6900Immune System
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_18277PERK regulates gene expression
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_18356Unfolded Protein Response (UPR)
SMP Pathway Links
SMP IDDescription
SMP00640Acetaminophen Metabolism Pathway
SMP00442Etoposide Action Pathway
SMP00601Etoposide Metabolism Pathway
SMP00086Ibuprofen Action Pathway
SMP00590Ibuprofen Metabolism Pathway
SMP00433Irinotecan Action Pathway
SMP00600Irinotecan Metabolism Pathway
SMP00406Morphine Action Pathway
SMP00622Morphine Metabolism Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00074Retinol Metabolism
SMP00648Sorafenib Metabolism Pathway
SMP00336Vitamin A Deficiency
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