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MGP001516

UniProt Annotations

Entry Information
Gene Nameheat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Protein EntryGRP78_HUMAN
UniProt IDP11021
SpeciesHuman
Comments
Comment typeDescription
DiseaseNote=Autoantigen in rheumatoid arthritis. {ECO:0000269|PubMed:11160188}.
FunctionProbably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. {ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668}.
InteractionQ6T424:-; NbExp=3; IntAct=EBI-354921, EBI-7888150; P31749:AKT1; NbExp=2; IntAct=EBI-354921, EBI-296087; Q6E0U4:DMKN; NbExp=3; IntAct=EBI-354921, EBI-7943171; Q9UBS4:DNAJB11; NbExp=2; IntAct=EBI-354921, EBI-713113; Q91YW3:Dnajc3 (xeno); NbExp=2; IntAct=EBI-354921, EBI-8381770; Q96IZ0:PAWR; NbExp=8; IntAct=EBI-354921, EBI-595869; Q62627:Pawr (xeno); NbExp=4; IntAct=EBI-354921, EBI-1187240; P04049:RAF1; NbExp=4; IntAct=EBI-354921, EBI-365996; P61619:SEC61A1; NbExp=3; IntAct=EBI-354921, EBI-358919;
SimilarityBelongs to the heat shock protein 70 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum lumen. Melanosome. Cytoplasm {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitInteracts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. Interacts with DNAJC10 and MX1. Interacts with METTL23. Interacts with CEMIP; the interaction induces calcium leakage from the endoplamic reticulum and cell migration. {ECO:0000250, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:12699405, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18502753, ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HSPA5ID40876ch9q33.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa5/";
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