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MGP001544

Record overview

MGPD IDMGP001544
Gene ID3381
SpeciesHomo sapiens (Human)
Gene Nameintegrin-binding sialoprotein
Gene Symbol IBSP
SynonymsBSP; BNSP; SP-II; BSP-II;
Alternate namesbone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein;
Chromosome4
Map Location4q21.1
SummaryThe protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IBSP

Proteins

bone sialoprotein 2 precursor
Refseq ID:NP_004958
Protein GI:167466187
UniProt ID:P21815
mRNA ID:NM_004967
Length:317
RefSeq Status:
MKTALILLSILGMACAFSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRFPVQGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDS
EAENTTLSATTLGYGEDATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTSTNSTEAENGNGSSGGDNGEE
GEEESVTGANAEDTTETGRQGKGTSKTTTSPNGGFEPTTPPQVYRTTSPPFGKTTTVEYEGEYEYTGANEYDNGYEIYESENGEPRGDNYRAYEDEYSYF
KGQGYDGYDGQNYYHHQ
 
sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1649
peptide sequence: 
MKTALILLSILGMACA

mat_peptide: 17..317
product: bone sialoprotein 2
calculated_mol_wt: 33517
peptide sequence: 
FSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRFPVQGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEAENTTLSATTLGYGE
DATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTSTNSTEAENGNGSSGGDNGEEGEEESVTGANAEDTTE
TGRQGKGTSKTTTSPNGGFEPTTPPQVYRTTSPPFGKTTTVEYEGEYEYTGANEYDNGYEIYESENGEPRGDNYRAYEDEYSYFKGQGYDGYDGQNYYHH
Q
 
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