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MGP001544

UniProt Annotations

Entry Information
Gene Nameintegrin-binding sialoprotein
Protein EntrySIAL_HUMAN
UniProt IDP21815
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
MiscellaneousIt is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.
PtmN-glycosylated; glycans consist of sialylated and core- fucosylated bi-, tri- and tetraantennary chains. {ECO:0000269|PubMed:11459848}.
PtmO-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. {ECO:0000269|PubMed:11459848}.
PtmSulfated on either Tyr-313 or Tyr-314. {ECO:0000269|PubMed:11669636}.
Subcellular LocationSecreted.
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