MGP Database

MGP001545

Ontology/Pathway Information

Entrez Gene ID	3383
Gene Name	intercellular adhesion molecule 1
Gene Symbol	ICAM1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0001772	IEA:Ensembl	C	immunological synapse
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0016020	IDA:UniProtKB	C	membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0005178	IPI:BHF-UCL	F	integrin binding
GO:0004872	TAS:ProtInc	F	receptor activity
GO:0004888	TAS:ProtInc	F	transmembrane signaling receptor activity
GO:0001618	IEA:UniProtKB-KW	F	virus receptor activity
GO:0002438	IEA:Ensembl	P	acute inflammatory response to antigenic stimulus
GO:0044406	IDA:BHF-UCL	P	adhesion of symbiont to host
GO:0007155	IDA:BHF-UCL	P	cell adhesion
GO:0033627	IEA:Ensembl	P	cell adhesion mediated by integrin
GO:0007569	IEA:Ensembl	P	cell aging
GO:0071312	IEA:Ensembl	P	cellular response to alkaloid
GO:0071333	IEA:Ensembl	P	cellular response to glucose stimulus
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0071347	IEA:Ensembl	P	cellular response to interleukin-1
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0031669	IEA:Ensembl	P	cellular response to nutrient levels
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0019221	TAS:Reactome	P	cytokine-mediated signaling pathway
GO:0061028	IGI:UniProtKB	P	establishment of endothelial barrier
GO:0097368	IEA:Ensembl	P	establishment of Sertoli cell barrier
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0007157	TAS:BHF-UCL	P	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0060333	TAS:Reactome	P	interferon-gamma-mediated signaling pathway
GO:0007159	IMP:BHF-UCL	P	leukocyte cell-cell adhesion
GO:0050900	IEP:BHF-UCL	P	leukocyte migration
GO:0022614	IEP:BHF-UCL	P	membrane to membrane docking
GO:0051926	IEA:Ensembl	P	negative regulation of calcium ion transport
GO:2000352	IDA:BHF-UCL	P	negative regulation of endothelial cell apoptotic process
GO:1902042	IDA:BHF-UCL	P	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0001541	IEA:Ensembl	P	ovarian follicle development
GO:0030838	IEA:Ensembl	P	positive regulation of actin filament polymerization
GO:0002693	IMP:BHF-UCL	P	positive regulation of cellular extravasation
GO:0070374	IMP:BHF-UCL	P	positive regulation of ERK1 and ERK2 cascade
GO:0051092	IEA:Ensembl	P	positive regulation of NF-kappaB transcription factor activity
GO:0045429	IEA:Ensembl	P	positive regulation of nitric oxide biosynthetic process
GO:0050731	IEA:Ensembl	P	positive regulation of peptidyl-tyrosine phosphorylation
GO:0032321	IEA:Ensembl	P	positive regulation of Rho GTPase activity
GO:0045907	IEA:Ensembl	P	positive regulation of vasoconstriction
GO:0046813	IDA:BHF-UCL	P	receptor-mediated virion attachment to host cell
GO:0030155	IEA:Ensembl	P	regulation of cell adhesion
GO:0008360	IEA:Ensembl	P	regulation of cell shape
GO:0050776	TAS:Reactome	P	regulation of immune response
GO:0001910	TAS:BHF-UCL	P	regulation of leukocyte mediated cytotoxicity
GO:1900027	IEA:Ensembl	P	regulation of ruffle assembly
GO:0043200	IEA:Ensembl	P	response to amino acid
GO:0001975	IEA:Ensembl	P	response to amphetamine
GO:0046688	IEA:Ensembl	P	response to copper ion
GO:0042493	IEA:Ensembl	P	response to drug
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0034698	IEA:Ensembl	P	response to gonadotropin
GO:0010212	IEA:Ensembl	P	response to ionizing radiation
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0010477	IEA:Ensembl	P	response to sulfur dioxide
GO:0007605	IEA:Ensembl	P	sensory perception of sound
GO:0002291	IMP:BHF-UCL	P	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0002457	IEA:Ensembl	P	T cell antigen processing and presentation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75774	Adaptive Immune System
REACT_75790	Cytokine Signaling in Immune system
REACT_118779	Extracellular matrix organization
REACT_6900	Immune System
REACT_11152	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_13552	Integrin cell surface interactions
REACT_25078	Interferon gamma signaling
REACT_25229	Interferon Signaling