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MGP001545

UniProt Annotations

Entry Information
Gene Nameintercellular adhesion molecule 1
Protein EntryICAM1_HUMAN
UniProt IDP05362
SpeciesHuman
Comments
Comment typeDescription
FunctionICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.
PolymorphismHomozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIM:611162].
PtmMonoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
SimilarityBelongs to the immunoglobulin superfamily. ICAM family. {ECO:0000305}.
SimilarityContains 5 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHomodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:12526797, ECO:0000269|PubMed:15099525, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:9539703, ECO:0000305}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ICAM1ID40909ch19p13.html";
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=ICAM-1; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_261";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/icam1/";
Web ResourceName=Virus Particle ExploreR db; Note=Icosahedral capsid structure; URL="http://viperdb.scripps.edu/info_page.php?VDB=1z7z";
Web ResourceName=Wikipedia; Note=Intercellular adhesion molecule entry; URL="http://en.wikipedia.org/wiki/Intercellular_adhesion_molecule";
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