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MGP Database

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MGP001546

UniProt Annotations

Entry Information

Gene Name	intercellular adhesion molecule 2
Protein Entry	ICAM2_HUMAN
UniProt ID	P13598
Species	Human

Comments

Comment type	Description
Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Similarity	Belongs to the immunoglobulin superfamily. ICAM family. {ECO:0000305}.
Similarity	Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Web Resource	Name=Functional Glycomics Gateway - Glycan Binding; Note=ICAM-2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_262";