MGP Database

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MGP001547

Record overview

MGPD IDMGP001547
Gene ID3385
SpeciesHomo sapiens (Human)
Gene Nameintercellular adhesion molecule 3
Gene Symbol ICAM3
SynonymsCD50; CDW50; ICAM-R;
Alternate namesintercellular adhesion molecule 3; ICAM-3; intercellular adhesion molecule-3;
Chromosome19
Map Location19p13.3-p13.2
SummaryThe protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ICAM3

Proteins

intercellular adhesion molecule 3 precursor
Refseq ID:NP_002153
Protein GI:167466207
UniProt ID:P32942
mRNA ID:NM_002162
Length:547
RefSeq Status:
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYC
NGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQG
LGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGG
ERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGP
KIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVV
TIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
 
sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3147
peptide sequence: 
MATMVPSVLWPRACWTLLVCCLLTPGVQG

mat_peptide: 30..547
product: intercellular adhesion molecule 3
calculated_mol_wt: 56412
peptide sequence: 
QEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQ
PVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPR
FLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEG
STVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNP
YPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLP
LTSMQPTEAMGEEPSRAE
 
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