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MGP001547

UniProt Annotations

Entry Information
Gene Nameintercellular adhesion molecule 3
Protein EntryICAM3_HUMAN
UniProt IDP32942
SpeciesHuman
Comments
Comment typeDescription
FunctionICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.
PtmN-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. {ECO:0000269|PubMed:15728350, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973}.
PtmUpon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
SimilarityBelongs to the immunoglobulin superfamily. ICAM family. {ECO:0000305}.
SimilarityContains 5 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=ICAM-3; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_263";
Web ResourceName=R&D Systems' cytokine source book: ICAM-3; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1589";
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