Log in / Register

MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MGP001549

Ontology/Pathway Information

Entrez Gene ID	3394
Gene Name	interferon regulatory factor 8
Gene Symbol	IRF8
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0000975	IEA:InterPro	F	regulatory region DNA binding
GO:0003705	TAS:ProtInc	F	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0019221	TAS:Reactome	P	cytokine-mediated signaling pathway
GO:0042742	IEA:Ensembl	P	defense response to bacterium
GO:0042832	IEA:Ensembl	P	defense response to protozoan
GO:0006955	TAS:ProtInc	P	immune response
GO:0060333	TAS:Reactome	P	interferon-gamma-mediated signaling pathway
GO:0030099	IEA:Ensembl	P	myeloid cell differentiation
GO:0044130	IEA:Ensembl	P	negative regulation of growth of symbiont in host
GO:0000122	TAS:ProtInc	P	negative regulation of transcription from RNA polymerase II promoter
GO:0006909	IEA:Ensembl	P	phagocytosis
GO:0032729	IEA:Ensembl	P	positive regulation of interferon-gamma production
GO:0032735	IEA:Ensembl	P	positive regulation of interleukin-12 production
GO:0060261	IEA:Ensembl	P	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0006366	TAS:GOC	P	transcription from RNA polymerase II promoter
GO:0060337	TAS:Reactome	P	type I interferon signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75790	Cytokine Signaling in Immune system
REACT_6900	Immune System
REACT_25162	Interferon alpha/beta signaling
REACT_25078	Interferon gamma signaling
REACT_25229	Interferon Signaling