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MGP Database

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MGP001551

UniProt Annotations

Entry Information

Gene Name	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Protein Entry	ID1_HUMAN
UniProt ID	P41134
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=ID-A; IsoId=P41134-1; Sequence=Displayed; Name=ID-B; IsoId=P41134-2; Sequence=VSP_002108;
Developmental Stage	Expression correlates with proliferation in some types of cells.
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
Interaction	O14936:CASK; NbExp=3; IntAct=EBI-1215527, EBI-1215506; Q03135:CAV1; NbExp=6; IntAct=EBI-1215527, EBI-603614;
Similarity	Contains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255\|PROSITE-ProRule:PRU00981}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus.
Subunit	Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1. {ECO:0000250, ECO:0000269\|PubMed:20861012}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ID1ID40914ch20q11.html";