MGP Database

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MGP001552

Ontology/Pathway Information

Entrez Gene ID3417
Gene Nameisocitrate dehydrogenase 1 (NADP+), soluble
Gene Symbol IDH1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:LIFEdbCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005782 TAS:ReactomeCperoxisomal matrix
GO:0005777 IDA:UniProtKBCperoxisome
GO:0004450 IDA:UniProtKBFisocitrate dehydrogenase (NADP+) activity
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0051287 IEA:InterProFNAD binding
GO:0050661 IEA:EnsemblFNADP binding
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0006103 IDA:UniProtKBP2-oxoglutarate metabolic process
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0008585 IEA:EnsemblPfemale gonad development
GO:0006749 IEA:EnsemblPglutathione metabolic process
GO:0006097 IEA:UniProtKB-KWPglyoxylate cycle
GO:0006102 IDA:UniProtKBPisocitrate metabolic process
GO:0006740 TAS:ReactomePNADPH regeneration
GO:0006979 IEA:EnsemblPresponse to oxidative stress
GO:0048545 IEA:EnsemblPresponse to steroid hormone
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006099 IEA:UniProtKB-KWPtricarboxylic acid cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_160183Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
REACT_116125Disease
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_16904NADPH regeneration
REACT_16957Peroxisomal lipid metabolism
SMP Pathway Links
SMP IDDescription
SMP00654Warburg Effect
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