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MGP001554

Record overview

MGPD IDMGP001554
Gene ID3419
SpeciesHomo sapiens (Human)
Gene Nameisocitrate dehydrogenase 3 (NAD+) alpha
Gene Symbol IDH3A
Alternate namesisocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; H-IDH alpha; NAD(+)-specific ICDH subunit alpha; NAD(H)-specific isocitrate dehydrogenase alpha subunit; NAD+-specific ICDH; isocitrate dehydrogenase (NAD+) alpha chain; isocitric dehydrogenase subunit alpha;
Chromosome15
Map Location15q25.1-q25.2
EC Number1.1.1.41
SummaryIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IDH3A

Proteins

isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor
Refseq ID:NP_005521
Protein GI:5031777
UniProt ID:P50213
mRNA ID:NM_005530
Length:366
RefSeq Status:
MAGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLK
TPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHK
ANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKD
MANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD
 
transit_peptide: 1..27
calculated_mol_wt: 2970
peptide sequence: 
MAGPAWISKVSRLLGAFHNPKQVTRGF

mat_peptide: 28..366
product: isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
calculated_mol_wt: 36640
peptide sequence: 
TGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPC
VSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKF
NEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARI
EAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD
 
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