MGP Database

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MGP001554

UniProt Annotations

Entry Information
Gene Nameisocitrate dehydrogenase 3 (NAD+) alpha
Protein EntryIDH3A_HUMAN
UniProt IDP50213
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50213-1; Sequence=Displayed; Name=2; IsoId=P50213-2; Sequence=VSP_014516; Note=No experimental confirmation available.;
Catalytic ActivityIsocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO:0000250};
SimilarityBelongs to the isocitrate and isopropylmalate dehydrogenases family. {ECO:0000305}.
Subcellular LocationMitochondrion.
SubunitHeterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1. {ECO:0000250}.
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