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MGP001557

Record overview

MGPD IDMGP001557
Gene ID3422
SpeciesHomo sapiens (Human)
Gene Nameisopentenyl-diphosphate delta isomerase 1
Gene Symbol IDI1
SynonymsIPP1; IPPI1;
Alternate namesisopentenyl-diphosphate Delta-isomerase 1; IPP isomerase 1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1;
Chromosome10
Map Location10p15.3
EC Number5.3.3.2
SummaryIDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IDI1

Proteins

isopentenyl-diphosphate Delta-isomerase 1
Refseq ID:NP_004499
Protein GI:40018633
UniProt ID:Q13907
mRNA ID:NM_004508
Length:284
RefSeq Status:
MWRGLALARAIGCAARGRGQWAVRAADCAQSGRHPGPAVVCGRRLISVLEQIRHFVMMPEINTNHLDKQQVQLLAEMCILIDENDNKIGAETKKNCHLNE
NIEKGLLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNTCCSHPLSNPAELEESDALGVRRAAQRRLKAELGIPLEEVPPEEINYLTRIHYKAQSDGI
WGEHEIDYILLVRKNVTLNPDPNEIKSYCYVSKEELKELLKKAASGEIKITPWFKIIAATFLFKWWDNLNHLNQFVDHEKIYRM
 
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